1tvk

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[[Image:1tvk.gif|left|200px]]<br /><applet load="1tvk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1tvk.gif|left|200px]]
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caption="1tvk, resolution 2.89&Aring;" />
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'''The binding mode of epothilone A on a,b-tubulin by electron crystallography'''<br />
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{{Structure
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|PDB= 1tvk |SIZE=350|CAPTION= <scene name='initialview01'>1tvk</scene>, resolution 2.89&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene> and <scene name='pdbligand=EP:EPOTHILONE A'>EP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''The binding mode of epothilone A on a,b-tubulin by electron crystallography'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1TVK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=GDP:'>GDP</scene>, <scene name='pdbligand=GTP:'>GTP</scene> and <scene name='pdbligand=EP:'>EP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVK OCA].
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1TVK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVK OCA].
==Reference==
==Reference==
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The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography., Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH, Science. 2004 Aug 6;305(5685):866-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15297674 15297674]
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The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography., Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH, Science. 2004 Aug 6;305(5685):866-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15297674 15297674]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: GDP]]
[[Category: GDP]]
[[Category: GTP]]
[[Category: GTP]]
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[[Category: epothilone; taxol; ligand interactions]]
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[[Category: epothilone; taxol; ligand interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:17:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:23:49 2008''

Revision as of 12:23, 20 March 2008

Image:1tvk.gif


PDB ID 1tvk

Drag the structure with the mouse to rotate
, resolution 2.89Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



The binding mode of epothilone A on a,b-tubulin by electron crystallography


Overview

The structure of epothilone A, bound to alpha,beta-tubulin in zinc-stabilized sheets, was determined by a combination of electron crystallography at 2.89 angstrom resolution and nuclear magnetic resonance-based conformational analysis. The complex explains both the broad-based epothilone structure-activity relationship and the known mutational resistance profile. Comparison with Taxol shows that the longstanding expectation of a common pharmacophore is not met, because each ligand exploits the tubulin-binding pocket in a unique and independent manner.

About this Structure

1TVK is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography., Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH, Science. 2004 Aug 6;305(5685):866-9. PMID:15297674

Page seeded by OCA on Thu Mar 20 14:23:49 2008

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