1tz6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1tz6.gif|left|200px]]<br /><applet load="1tz6" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1tz6.gif|left|200px]]
-
caption="1tz6, resolution 2.70&Aring;" />
+
 
-
'''Crystal structure of aminoimidazole riboside kinase from Salmonella enterica complexed with aminoimidazole riboside and ATP analog'''<br />
+
{{Structure
 +
|PDB= 1tz6 |SIZE=350|CAPTION= <scene name='initialview01'>1tz6</scene>, resolution 2.70&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene> and <scene name='pdbligand=AIS:5-AMINOIMIDAZOLE RIBONUCLEOSIDE'>AIS</scene>
 +
|ACTIVITY= [http://en.wikipedia.org/wiki/Fructokinase Fructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.4 2.7.1.4]
 +
|GENE= Stm4066 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 Salmonella typhimurium LT2])
 +
}}
 +
 
 +
'''Crystal structure of aminoimidazole riboside kinase from Salmonella enterica complexed with aminoimidazole riboside and ATP analog'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1TZ6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_lt2 Salmonella typhimurium lt2] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=ACP:'>ACP</scene> and <scene name='pdbligand=AIS:'>AIS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fructokinase Fructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.4 2.7.1.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TZ6 OCA].
+
1TZ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_lt2 Salmonella typhimurium lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TZ6 OCA].
==Reference==
==Reference==
-
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily., Zhang Y, Dougherty M, Downs DM, Ealick SE, Structure. 2004 Oct;12(10):1809-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15458630 15458630]
+
Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily., Zhang Y, Dougherty M, Downs DM, Ealick SE, Structure. 2004 Oct;12(10):1809-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15458630 15458630]
[[Category: Fructokinase]]
[[Category: Fructokinase]]
[[Category: Salmonella typhimurium lt2]]
[[Category: Salmonella typhimurium lt2]]
Line 25: Line 34:
[[Category: ribokinase fold]]
[[Category: ribokinase fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:18:55 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:25:09 2008''

Revision as of 12:25, 20 March 2008

Image:1tz6.gif


PDB ID 1tz6

Drag the structure with the mouse to rotate
, resolution 2.70Å
Ligands: , , and
Gene: Stm4066 (Salmonella typhimurium LT2)
Activity: Fructokinase, with EC number 2.7.1.4
Coordinates: save as pdb, mmCIF, xml



Crystal structure of aminoimidazole riboside kinase from Salmonella enterica complexed with aminoimidazole riboside and ATP analog


Overview

The crystal structures of a Salmonella enterica aminoimidazole riboside (AIRs) kinase, its complex with the substrate AIRs, and its complex with AIRs and an ATP analog were determined at 2.6 angstroms, 2.9 angstroms, and 2.7 angstroms, respectively. The product of the Salmonella-specific gene stm4066, AIRs kinase, is a homodimer with one active site per monomer. The core structure, consisting of an eight-stranded beta sheet flanked by eight alpha helices, indicates that AIRs kinase is a member of the ribokinase superfamily. Unlike ribokinase and adenosine kinase in this superfamily, AIRs kinase does not show significant conformational changes upon substrate binding. The active site is covered by a lid formed by residues 16-28 and 86-100. A comparison of the structure of AIRs kinase with other ribokinase superfamily members suggests that the active site lid and conformational changes that occur upon substrate binding may be advanced features in the evolution of the ribokinase superfamily.

About this Structure

1TZ6 is a Single protein structure of sequence from Salmonella typhimurium lt2. Full crystallographic information is available from OCA.

Reference

Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily., Zhang Y, Dougherty M, Downs DM, Ealick SE, Structure. 2004 Oct;12(10):1809-21. PMID:15458630

Page seeded by OCA on Thu Mar 20 14:25:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tz6"
Personal tools