1u9k
From Proteopedia
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| - | [[Image:1u9k.jpg|left|200px]] | + | [[Image:1u9k.jpg|left|200px]] |
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| - | '''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76''' | + | {{Structure |
| + | |PDB= 1u9k |SIZE=350|CAPTION= <scene name='initialview01'>1u9k</scene>, resolution 1.76Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= trem ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1U9K is a [ | + | 1U9K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9K OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A., Kelker MS, Debler EW, Wilson IA, J Mol Biol. 2004 Dec 10;344(5):1175-81. PMID:[http:// | + | Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A., Kelker MS, Debler EW, Wilson IA, J Mol Biol. 2004 Dec 10;344(5):1175-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15561137 15561137] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
| - | [[Category: activating | + | [[Category: activating receptor]] |
[[Category: immune system receptor]] | [[Category: immune system receptor]] | ||
[[Category: innate immunity]] | [[Category: innate immunity]] | ||
[[Category: trem-1]] | [[Category: trem-1]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:29:05 2008'' |
Revision as of 12:29, 20 March 2008
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| , resolution 1.76Å | |||||||
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| Ligands: | |||||||
| Gene: | trem (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76
Overview
Triggering receptor expressed on myeloid cells (TREM) 1 is an activating receptor expressed on myeloid cells whose ligand(s) remain elusive. TREM-1 stimulation activates neutrophils and monocytes and induces the secretion of pro-inflammatory molecules, which amplifies the Toll-like receptor-initiated responses to invading pathogens. In addition, TREM-1 mediates the septic shock pathway, and thus represents a potential therapeutic target. We report the crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution. The mouse extracellular domain is monomeric, consistent with our previous human TREM-1 structure, and strongly supports the contention that the globular TREM-1 head is a monomer contrary to proposals of a symmetric dimer.
About this Structure
1U9K is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A., Kelker MS, Debler EW, Wilson IA, J Mol Biol. 2004 Dec 10;344(5):1175-81. PMID:15561137
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