1ua7
From Proteopedia
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| - | [[Image:1ua7.gif|left|200px]] | + | [[Image:1ua7.gif|left|200px]] |
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| - | '''Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose''' | + | {{Structure |
| + | |PDB= 1ua7 |SIZE=350|CAPTION= <scene name='initialview01'>1ua7</scene>, resolution 2.21Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UA7 is a [ | + | 1UA7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UA7 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose., Kagawa M, Fujimoto Z, Momma M, Takase K, Mizuno H, J Bacteriol. 2003 Dec;185(23):6981-4. PMID:[http:// | + | Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose., Kagawa M, Fujimoto Z, Momma M, Takase K, Mizuno H, J Bacteriol. 2003 Dec;185(23):6981-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14617662 14617662] |
[[Category: Alpha-amylase]] | [[Category: Alpha-amylase]] | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
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[[Category: CA]] | [[Category: CA]] | ||
[[Category: acarbose]] | [[Category: acarbose]] | ||
| - | [[Category: beta-alpha- | + | [[Category: beta-alpha-barrel]] |
[[Category: greek-key motif]] | [[Category: greek-key motif]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:29:18 2008'' |
Revision as of 12:29, 20 March 2008
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| , resolution 2.21Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Alpha-amylase, with EC number 3.2.1.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose
Overview
The crystal structure of Bacillus subtilis alpha-amylase, in complex with the pseudotetrasaccharide inhibitor acarbose, revealed an hexasaccharide in the active site as a result of transglycosylation. After comparison with the known structure of the catalytic-site mutant complexed with the native substrate maltopentaose, it is suggested that the present structure represents a mimic intermediate in the initial stage of the catalytic process.
About this Structure
1UA7 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose., Kagawa M, Fujimoto Z, Momma M, Takase K, Mizuno H, J Bacteriol. 2003 Dec;185(23):6981-4. PMID:14617662
Page seeded by OCA on Thu Mar 20 14:29:18 2008
