1ub4

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[[Image:1ub4.gif|left|200px]]<br /><applet load="1ub4" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ub4.gif|left|200px]]
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caption="1ub4, resolution 1.70&Aring;" />
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'''crystal structure of MazEF complex'''<br />
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{{Structure
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|PDB= 1ub4 |SIZE=350|CAPTION= <scene name='initialview01'>1ub4</scene>, resolution 1.70&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= mazF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), MazE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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}}
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'''crystal structure of MazEF complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1UB4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UB4 OCA].
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1UB4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UB4 OCA].
==Reference==
==Reference==
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Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition., Kamada K, Hanaoka F, Burley SK, Mol Cell. 2003 Apr;11(4):875-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12718874 12718874]
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Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition., Kamada K, Hanaoka F, Burley SK, Mol Cell. 2003 Apr;11(4):875-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12718874 12718874]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: toxin]]
[[Category: toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:22:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:29:38 2008''

Revision as of 12:29, 20 March 2008

Image:1ub4.gif


PDB ID 1ub4

Drag the structure with the mouse to rotate
, resolution 1.70Å
Gene: mazF (Escherichia coli), MazE (Escherichia coli)
Coordinates: save as pdb, mmCIF, xml



crystal structure of MazEF complex


Overview

A structure of the Escherichia coli chromosomal MazE/MazF addiction module has been determined at 1.7 A resolution. Addiction modules consist of stable toxin and unstable antidote proteins that govern bacterial cell death. MazE (antidote) and MazF (toxin) form a linear heterohexamer composed of alternating toxin and antidote homodimers (MazF(2)-MazE(2)-MazF(2)). The MazE homodimer contains a beta barrel from which two extended C termini project, making interactions with flanking MazF homodimers that resemble the plasmid-encoded toxins CcdB and Kid. The MazE/MazF heterohexamer structure documents that the mechanism of antidote-toxin recognition is common to both chromosomal and plasmid-borne addiction modules, and provides general molecular insights into toxin function, antidote degradation in the absence of toxin, and promoter DNA binding by antidote/toxin complexes.

About this Structure

1UB4 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition., Kamada K, Hanaoka F, Burley SK, Mol Cell. 2003 Apr;11(4):875-84. PMID:12718874

Page seeded by OCA on Thu Mar 20 14:29:38 2008

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