1uct
From Proteopedia
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| - | [[Image:1uct.jpg|left|200px]] | + | [[Image:1uct.jpg|left|200px]] |
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| - | '''Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)''' | + | {{Structure |
| + | |PDB= 1uct |SIZE=350|CAPTION= <scene name='initialview01'>1uct</scene>, resolution 2.1Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UCT is a [ | + | 1UCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCT OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the ectodomain of human FcalphaRI., Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z, J Biol Chem. 2003 Jul 25;278(30):27966-70. Epub 2003 Jun 3. PMID:[http:// | + | Crystal structure of the ectodomain of human FcalphaRI., Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z, J Biol Chem. 2003 Jul 25;278(30):27966-70. Epub 2003 Jun 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12783876 12783876] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Yang, M.]] | [[Category: Yang, M.]] | ||
[[Category: Zhang, W.]] | [[Category: Zhang, W.]] | ||
| - | [[Category: beta | + | [[Category: beta stand]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:30:19 2008'' |
Revision as of 12:30, 20 March 2008
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| , resolution 2.1Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)
Overview
Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs. In this work, we analyzed the crystal structure of the ectodomain of FcalphaRI and examined structure similarities between FcalphaRI and KIR2DL1, KIR2DL2 and LIR-1. Our data show that FcalphaRI, KIRs, and LIRs share a common hydrophobic core in their interdomain interface, and FcalphaRI is evolutionally closer to LIR than KIR.
About this Structure
1UCT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ectodomain of human FcalphaRI., Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z, J Biol Chem. 2003 Jul 25;278(30):27966-70. Epub 2003 Jun 3. PMID:12783876
Page seeded by OCA on Thu Mar 20 14:30:19 2008
Categories: Homo sapiens | Single protein | Ding, Y. | Rao, Z. | Xu, G. | Yang, M. | Zhang, W. | Beta stand
