1uor

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[[Image:1uor.gif|left|200px]]<br /><applet load="1uor" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1uor.gif|left|200px]]
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caption="1uor, resolution 2.80&Aring;" />
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'''X-RAY STUDY OF RECOMBINANT HUMAN SERUM ALBUMIN. PHASES DETERMINED BY MOLECULAR REPLACEMENT METHOD, USING LOW RESOLUTION STRUCTURE MODEL OF TETRAGONAL FORM OF HUMAN SERUM ALBUMIN'''<br />
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{{Structure
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|PDB= 1uor |SIZE=350|CAPTION= <scene name='initialview01'>1uor</scene>, resolution 2.80&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''X-RAY STUDY OF RECOMBINANT HUMAN SERUM ALBUMIN. PHASES DETERMINED BY MOLECULAR REPLACEMENT METHOD, USING LOW RESOLUTION STRUCTURE MODEL OF TETRAGONAL FORM OF HUMAN SERUM ALBUMIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1UOR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOR OCA].
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1UOR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOR OCA].
==Reference==
==Reference==
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Atomic structure and chemistry of human serum albumin., He XM, Carter DC, Nature. 1992 Jul 16;358(6383):209-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1630489 1630489]
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Atomic structure and chemistry of human serum albumin., He XM, Carter DC, Nature. 1992 Jul 16;358(6383):209-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1630489 1630489]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: plasma protein]]
[[Category: plasma protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:26:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:34:49 2008''

Revision as of 12:34, 20 March 2008

Image:1uor.gif


PDB ID 1uor

Drag the structure with the mouse to rotate
, resolution 2.80Å
Coordinates: save as pdb, mmCIF, xml



X-RAY STUDY OF RECOMBINANT HUMAN SERUM ALBUMIN. PHASES DETERMINED BY MOLECULAR REPLACEMENT METHOD, USING LOW RESOLUTION STRUCTURE MODEL OF TETRAGONAL FORM OF HUMAN SERUM ALBUMIN


Contents

Overview

The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.

Disease

Known diseases associated with this structure: Analbuminemia OMIM:[103600], Dysalbuminemic hyperthyroxinemia OMIM:[103600], Dysalbuminemic hyperzincemia OMIM:[103600]

About this Structure

1UOR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Atomic structure and chemistry of human serum albumin., He XM, Carter DC, Nature. 1992 Jul 16;358(6383):209-15. PMID:1630489

Page seeded by OCA on Thu Mar 20 14:34:49 2008

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