1urj

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[[Image:1urj.gif|left|200px]]<br /><applet load="1urj" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1urj.gif|left|200px]]
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caption="1urj, resolution 3.0&Aring;" />
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'''SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1'''<br />
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{{Structure
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|PDB= 1urj |SIZE=350|CAPTION= <scene name='initialview01'>1urj</scene>, resolution 3.0&Aring;
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|SITE= <scene name='pdbsite=AC1:Hg+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=HG:MERCURY (II) ION'>HG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1URJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=HG:'>HG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Hg+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URJ OCA].
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1URJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URJ OCA].
==Reference==
==Reference==
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The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding., Mapelli M, Panjikar S, Tucker PA, J Biol Chem. 2005 Jan 28;280(4):2990-7. Epub 2004 Oct 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15507432 15507432]
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The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding., Mapelli M, Panjikar S, Tucker PA, J Biol Chem. 2005 Jan 28;280(4):2990-7. Epub 2004 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15507432 15507432]
[[Category: Human herpesvirus 4]]
[[Category: Human herpesvirus 4]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc-finger]]
[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:27:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:35:45 2008''

Revision as of 12:35, 20 March 2008

Image:1urj.gif


PDB ID 1urj

Drag the structure with the mouse to rotate
, resolution 3.0Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



SINGLE STRANDED DNA-BINDING PROTEIN(ICP8) FROM HERPES SIMPLEX VIRUS-1


Overview

All organisms including animal viruses use specific proteins to bind single-stranded DNA rapidly in a non-sequence-specific, flexible, and cooperative manner during the DNA replication process. The crystal structure of a 60-residue C-terminal deletion construct of ICP8, the major single-stranded DNA-binding protein from herpes simplex virus-1, was determined at 3.0 A resolution. The structure reveals a novel fold, consisting of a large N-terminal domain (residues 9-1038) and a small C-terminal domain (residues 1049-1129). On the basis of the structure and the nearest neighbor interactions in the crystal, we have presented a model describing the site of single-stranded DNA binding and explaining the basis for cooperative binding. This model agrees with the beaded morphology observed in electron micrographs.

About this Structure

1URJ is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding., Mapelli M, Panjikar S, Tucker PA, J Biol Chem. 2005 Jan 28;280(4):2990-7. Epub 2004 Oct 26. PMID:15507432

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