1urn

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[[Image:1urn.jpg|left|200px]]<br /><applet load="1urn" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1urn.jpg|left|200px]]
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caption="1urn, resolution 1.920&Aring;" />
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'''U1A MUTANT/RNA COMPLEX + GLYCEROL'''<br />
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{{Structure
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|PDB= 1urn |SIZE=350|CAPTION= <scene name='initialview01'>1urn</scene>, resolution 1.920&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''U1A MUTANT/RNA COMPLEX + GLYCEROL'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1URN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URN OCA].
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1URN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1URN OCA].
==Reference==
==Reference==
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Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7984237 7984237]
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Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7984237 7984237]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: single strand]]
[[Category: single strand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:27:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:35:56 2008''

Revision as of 12:35, 20 March 2008

Image:1urn.jpg


PDB ID 1urn

Drag the structure with the mouse to rotate
, resolution 1.920Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



U1A MUTANT/RNA COMPLEX + GLYCEROL


Overview

The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been determined at 1.92 A resolution. The ten-nucleotide RNA loop binds to the surface of the beta-sheet as an open structure, and the AUUGCAC sequence of the loop interacts extensively with the conserved RNP1 and RNP2 motifs and the C-terminal extension of the RNP domain. These interactions include stacking of RNA bases with aromatic side chains of proteins and many direct and water-mediated hydrogen bonds. The structure reveals the stereochemical basis for sequence-specific RNA recognition by the RNP domain.

About this Structure

1URN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:7984237

Page seeded by OCA on Thu Mar 20 14:35:56 2008

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