1utr
From Proteopedia
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| - | [[Image:1utr.jpg|left|200px]] | + | [[Image:1utr.jpg|left|200px]] |
| - | + | ||
| - | '''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)''' | + | {{Structure |
| + | |PDB= 1utr |SIZE=350|CAPTION= <scene name='initialview01'>1utr</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PCB:4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL'>PCB</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | }} | ||
| + | |||
| + | '''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UTR is a [ | + | 1UTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:[http:// | + | Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583672 7583672] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: uteroglobin]] | [[Category: uteroglobin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:36:38 2008'' |
Revision as of 12:36, 20 March 2008
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| Ligands: | |||||||
| Gene: | POTENTIAL (Rattus norvegicus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)
Overview
Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.
About this Structure
1UTR is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:7583672
Page seeded by OCA on Thu Mar 20 14:36:38 2008
