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1fvv

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1fvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FVV FirstGlance]. <br>
<table><tr><td colspan='2'>[[1fvv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FVV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=107:4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE'>107</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=107:4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE'>107</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fvv RCSB], [http://www.ebi.ac.uk/pdbsum/1fvv PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fvv RCSB], [http://www.ebi.ac.uk/pdbsum/1fvv PDBsum]</span></td></tr>
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<table>
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</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Transferase]]
[[Category: Transferase]]
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[[Category: Benson, B G.]]
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[[Category: Benson, B G]]
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[[Category: Bramson, H N.]]
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[[Category: Bramson, H N]]
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[[Category: Chapman, D E.]]
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[[Category: Chapman, D E]]
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[[Category: Davis, S T.]]
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[[Category: Davis, S T]]
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[[Category: Dickerson, S H.]]
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[[Category: Dickerson, S H]]
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[[Category: Dold, K M.]]
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[[Category: Dold, K M]]
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[[Category: Eberwein, D J.]]
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[[Category: Eberwein, D J]]
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[[Category: Edelstein, M.]]
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[[Category: Edelstein, M]]
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[[Category: Frye, S V.]]
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[[Category: Frye, S V]]
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[[Category: Gampe, R T.]]
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[[Category: Gampe, R T]]
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[[Category: Griffin, R J.]]
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[[Category: Griffin, R J]]
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[[Category: Harris, P A.]]
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[[Category: Harris, P A]]
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[[Category: Hassell, A M.]]
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[[Category: Hassell, A M]]
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[[Category: Holmes, W D.]]
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[[Category: Holmes, W D]]
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[[Category: Hunter, R N.]]
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[[Category: Hunter, R N]]
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[[Category: Knick, V B.]]
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[[Category: Knick, V B]]
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[[Category: Kuyper, L K.]]
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[[Category: Kuyper, L K]]
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[[Category: Lackey, K.]]
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[[Category: Lackey, K]]
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[[Category: Lovejoy, B.]]
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[[Category: Lovejoy, B]]
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[[Category: Luzzio, M J.]]
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[[Category: Luzzio, M J]]
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[[Category: Murray, D.]]
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[[Category: Murray, D]]
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[[Category: Parker, P.]]
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[[Category: Parker, P]]
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[[Category: Rocque, W J.]]
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[[Category: Rocque, W J]]
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[[Category: Shewchuk, L.]]
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[[Category: Shewchuk, L]]
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[[Category: Veal, J M.]]
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[[Category: Veal, J M]]
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[[Category: Walker, D H.]]
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[[Category: Walker, D H]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Cyclin some]]
[[Category: Cyclin some]]
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
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[[Category: Transferase]]
 

Revision as of 20:46, 22 December 2014

THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR

1fvv, resolution 2.80Å

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