1uw1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1uw1.jpg|left|200px]]<br /><applet load="1uw1" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1uw1.jpg|left|200px]]
-
caption="1uw1, resolution 1.94&Aring;" />
+
 
-
'''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''<br />
+
{{Structure
 +
|PDB= 1uw1 |SIZE=350|CAPTION= <scene name='initialview01'>1uw1</scene>, resolution 1.94&Aring;
 +
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
 +
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1UW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA].
+
1UW1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UW1 OCA].
==Reference==
==Reference==
-
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15024384 15024384]
+
A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15024384 15024384]
[[Category: ]]
[[Category: ]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 21: Line 30:
[[Category: nucleotide binding protein]]
[[Category: nucleotide binding protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:28:56 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:37:32 2008''

Revision as of 12:37, 20 March 2008

Image:1uw1.jpg


PDB ID 1uw1

Drag the structure with the mouse to rotate
, resolution 1.94Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION


Overview

A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion.

About this Structure

1UW1 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 [[Category: ]]

Page seeded by OCA on Thu Mar 20 14:37:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uw1"
Personal tools