1uzg

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[[Image:1uzg.gif|left|200px]]<br /><applet load="1uzg" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1uzg.gif|left|200px]]
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caption="1uzg, resolution 3.50&Aring;" />
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'''CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN'''<br />
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{{Structure
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|PDB= 1uzg |SIZE=350|CAPTION= <scene name='initialview01'>1uzg</scene>, resolution 3.50&Aring;
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|SITE= <scene name='pdbsite=AC1:Mutation+At+This+Position+Causes+Escape+From+Neutralizat+...'>AC1</scene>
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|LIGAND= <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene> and <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1UZG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_1 Dengue virus type 1] with <scene name='pdbligand=FUL:'>FUL</scene>, <scene name='pdbligand=BMA:'>BMA</scene> and <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Mutation+At+This+Position+Causes+Escape+From+Neutralizat+...'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZG OCA].
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1UZG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_1 Dengue virus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZG OCA].
==Reference==
==Reference==
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Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, J Virol. 2005 Jan;79(2):1223-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15613349 15613349]
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Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, J Virol. 2005 Jan;79(2):1223-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15613349 15613349]
[[Category: Dengue virus type 1]]
[[Category: Dengue virus type 1]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: virus/viral protein]]
[[Category: virus/viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:30:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:38:56 2008''

Revision as of 12:38, 20 March 2008

Image:1uzg.gif


PDB ID 1uzg

Drag the structure with the mouse to rotate
, resolution 3.50Å
Sites:
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE DENGUE TYPE 3 VIRUS ENVELOPE PROTEIN


Overview

Dengue virus is an emerging global health threat. The major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. Antibodies that bind but fail to neutralize noncognate serotypes enhance infection. We have determined the crystal structure of a soluble fragment of the envelope glycoprotein E from dengue virus type 3. The structure closely resembles those of E proteins from dengue type 2 and tick-borne encephalitis viruses. Serotype-specific neutralization escape mutants in dengue virus E proteins are all located on a surface of domain III, which has been implicated in receptor binding. While antibodies against epitopes in domain I are nonneutralizing in dengue virus, there are neutralizing antibodies that recognize serotype-conserved epitopes in domain II. The mechanism of neutralization for these antibodies is probably inhibition of membrane fusion. Our structure shows that neighboring glycans on the viral surface are spaced widely enough (at least 32 A) that they can interact with multiple carbohydrate recognition domains on oligomeric lectins such as DC-SIGN, ensuring maximum affinity for these putative receptors.

About this Structure

1UZG is a Single protein structure of sequence from Dengue virus type 1. Full crystallographic information is available from OCA.

Reference

Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, J Virol. 2005 Jan;79(2):1223-31. PMID:15613349

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