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1gh7
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1gh7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GH7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1gh7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GH7 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gh7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gh7 RCSB], [http://www.ebi.ac.uk/pdbsum/1gh7 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gh7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1gh7 RCSB], [http://www.ebi.ac.uk/pdbsum/1gh7 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[http://omim.org/entry/614370 614370]]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref> | [[http://www.uniprot.org/uniprot/IL3RB_HUMAN IL3RB_HUMAN]] Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:[http://omim.org/entry/614370 614370]]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:21075760</ref> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Carr, P D | + | [[Category: Carr, P D]] |
| - | [[Category: Church, A P | + | [[Category: Church, A P]] |
| - | [[Category: Ford, S C | + | [[Category: Ford, S C]] |
| - | [[Category: Gustin, S E | + | [[Category: Gustin, S E]] |
| - | [[Category: Mann, D A | + | [[Category: Mann, D A]] |
| - | [[Category: Murphy, J M | + | [[Category: Murphy, J M]] |
| - | [[Category: Ollis, D L | + | [[Category: Ollis, D L]] |
| - | [[Category: Walker, I | + | [[Category: Walker, I]] |
| - | [[Category: Woltring, D M | + | [[Category: Woltring, D M]] |
| - | [[Category: Young, I G | + | [[Category: Young, I G]] |
[[Category: Cytokine receptor]] | [[Category: Cytokine receptor]] | ||
[[Category: Dimer of interlocking chains of fibronectin-iii domains four fibronectin-iii domains per chain]] | [[Category: Dimer of interlocking chains of fibronectin-iii domains four fibronectin-iii domains per chain]] | ||
Revision as of 22:44, 22 December 2014
CRYSTAL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE BETA-COMMON RECEPTOR OF IL-3, IL-5, AND GM-CSF
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