This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1csl
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE== | |
| - | + | <StructureSection load='1csl' size='340' side='right' caption='[[1csl]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[1csl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CSL FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1csl RCSB], [http://www.ebi.ac.uk/pdbsum/1csl PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies. | ||
| - | + | The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution.,Ippolito JA, Steitz TA J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:10656783<ref>PMID:10656783</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Ippolito, J A | + | == References == |
| - | [[Category: Steitz, T A | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ippolito, J A]] | ||
| + | [[Category: Steitz, T A]] | ||
[[Category: Hiv-1]] | [[Category: Hiv-1]] | ||
[[Category: Rna]] | [[Category: Rna]] | ||
[[Category: Rre high affinity site]] | [[Category: Rre high affinity site]] | ||
Revision as of 00:05, 23 December 2014
CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE
| |||||||||||
