1csl
From Proteopedia
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| - | + | ==CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE== | |
| - | + | <StructureSection load='1csl' size='340' side='right' caption='[[1csl]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[1csl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CSL FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1csl RCSB], [http://www.ebi.ac.uk/pdbsum/1csl PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies. | ||
| - | + | The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution.,Ippolito JA, Steitz TA J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:10656783<ref>PMID:10656783</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Ippolito, J A | + | == References == |
| - | [[Category: Steitz, T A | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ippolito, J A]] | ||
| + | [[Category: Steitz, T A]] | ||
[[Category: Hiv-1]] | [[Category: Hiv-1]] | ||
[[Category: Rna]] | [[Category: Rna]] | ||
[[Category: Rre high affinity site]] | [[Category: Rre high affinity site]] | ||
Revision as of 00:05, 23 December 2014
CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE
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