From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 30: |
Line 30: |
| | === Structure === | | === Structure === |
| | | | |
| - | <ref>Stephen H Wile, William C Wimley and Michael E Selsted. Structure, function, and membrane integration of defensins. Current Opinion in Structural Biology 1995</ref>." | + | <ref>Stephen H Wile, William C Wimley and Michael E Selsted. Structure, function, and membrane integration of defensins. Current Opinion in Structural Biology 1995. University of California, Irvine, USA</ref>." |
| | | | |
| | {| align=center | | {| align=center |
Revision as of 10:15, 23 December 2014
| This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
|
To get started:
- Click the edit this page tab at the top. Save the page after each step, then edit it again.
- Click the 3D button (when editing, above the wikitext box) to insert Jmol.
- show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
- Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.
More help: Help:Editing
|
Defensins-Alpha-1 playing a role against trypanosoma cruzy
Introduction
Defensins (DEF) are a family of protein which are involved in host defenses in the epithelia of mucosal surfaces such as those of the intestin, respiratory tract, urinary tract, and vagina. There are antimicrobial and cytotoxic. All the protein of the family are distinguished by a cystein motif and are encoded on the chromozome 8 [1]. There are many defensin but in this article we will focus on the defensin alpha 1. The defensin alpha 1 is a polypeptide which are found in the microbicidal granules of neutrophils. They are syntetisize in the Paneth cell, which plays a role in the defense process. [2]It plays a role in phagocite-mediated host defense.
In this article, we will focus on the action of the alpha defensin 1 against the ' ' trypanosoma cruzy ' '.
|
Biological role
DEF are known to play a role in the in the initiation of innate immune responses to some microbial pathogens. For example the alpha defensin 1 have a role against the bacteria "Trypanosoma cruzi" [3]."Trypanosoma cruzy" or "Cruzy" debilitats Chagas disease, which affects millions of people and products significant morbidity and mortality. The defensine alpha 1 are secreted by the HCT116 cells (which are Paneth cells), when they are infect by "Cruzy". They reduces the infection making damage of the flagella structure. This damage inhibit parasite motility and reduce cellular infection. This reaction is introduce in the following drawing.
 Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway |
Structure
[4]."
 Defensin-Alpha-1 cysteine connectivities. |
References
- ↑ http://www.ncbi.nlm.nih.gov/gene/1667
- ↑ https://books.google.fr/books Histologie et biologie cellulaire: Une introduction à l'anatomie pathologique Abraham L. Kierszenbaum 2002
- ↑ http://iai.asm.org/content/81/11/4139.full/ref
- ↑ Stephen H Wile, William C Wimley and Michael E Selsted. Structure, function, and membrane integration of defensins. Current Opinion in Structural Biology 1995. University of California, Irvine, USA
Proteopedia page contributors and editors
|
