1vlk

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[[Image:1vlk.gif|left|200px]]<br /><applet load="1vlk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1vlk.gif|left|200px]]
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caption="1vlk, resolution 1.9&Aring;" />
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'''STRUCTURE OF VIRAL INTERLEUKIN-10'''<br />
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{{Structure
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|PDB= 1vlk |SIZE=350|CAPTION= <scene name='initialview01'>1vlk</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF VIRAL INTERLEUKIN-10'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1VLK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VLK OCA].
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1VLK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VLK OCA].
==Reference==
==Reference==
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Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10., Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A, J Mol Biol. 1997 May 2;268(2):460-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9159483 9159483]
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Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10., Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A, J Mol Biol. 1997 May 2;268(2):460-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9159483 9159483]
[[Category: Human herpesvirus 4]]
[[Category: Human herpesvirus 4]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: signal]]
[[Category: signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:36:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:47:11 2008''

Revision as of 12:47, 20 March 2008

Image:1vlk.gif


PDB ID 1vlk

Drag the structure with the mouse to rotate
, resolution 1.9Å
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF VIRAL INTERLEUKIN-10


Overview

The crystal structure of Epstein-Barr virus protein BCRF1, an analog of cellular interleukin-10 (IL-10), has been determined at the resolution of 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is similar to that of human IL-10 (hIL-10), forming an intercalated dimer of two 17 kDa polypeptides related by a crystallographic 2-fold symmetry axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the loop between helices A and B compared to hIL-10. These regions are likely to be involved in binding of one or more components of the IL-10 receptor system, and thus the structural differences may account for the lower binding affinity and limited spectrum of biological activities of viral IL-10, compared to hIL-10.

About this Structure

1VLK is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10., Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A, J Mol Biol. 1997 May 2;268(2):460-7. PMID:9159483

Page seeded by OCA on Thu Mar 20 14:47:11 2008

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