2y2b
From Proteopedia
(Difference between revisions)
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<StructureSection load='2y2b' size='340' side='right' caption='[[2y2b]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2y2b' size='340' side='right' caption='[[2y2b]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y2b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y2B OCA]. <br> | + | <table><tr><td colspan='2'>[[2y2b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_freundii Citrobacter freundii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y2B FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AH0:2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC+ACID'>AH0</scene>, <scene name='pdbligand=MHI:L-ALA-GAMMA-D-GLU-MESO-DIAMINOPIMELIC+ACID'>MHI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AH0:2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC+ACID'>AH0</scene>, <scene name='pdbligand=MHI:L-ALA-GAMMA-D-GLU-MESO-DIAMINOPIMELIC+ACID'>MHI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j3g|1j3g]], [[2y2c|2y2c]], [[2y2d|2y2d]], [[2y2e|2y2e]], [[2y28|2y28]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j3g|1j3g]], [[2y2c|2y2c]], [[2y2d|2y2d]], [[2y2e|2y2e]], [[2y28|2y28]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylmuramoyl-L-alanine_amidase N-acetylmuramoyl-L-alanine amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.28 3.5.1.28] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y2b RCSB], [http://www.ebi.ac.uk/pdbsum/2y2b PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y2b RCSB], [http://www.ebi.ac.uk/pdbsum/2y2b PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AMPD_CITFR AMPD_CITFR]] Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Crystal Structures of Bacterial Peptidoglycan Amidase AmpD and an Unprecedented Activation Mechanism.,Carrasco-Lopez C, Rojas-Altuve A, Zhang W, Hesek D, Lee M, Barbe S, Andre I, Ferrer P, Silva-Martin N, Castro GR, Martinez-Ripoll M, Mobashery S, Hermoso JA J Biol Chem. 2011 Sep 9;286(36):31714-22. Epub 2011 Jul 20. PMID:21775432<ref>PMID:21775432</ref> | Crystal Structures of Bacterial Peptidoglycan Amidase AmpD and an Unprecedented Activation Mechanism.,Carrasco-Lopez C, Rojas-Altuve A, Zhang W, Hesek D, Lee M, Barbe S, Andre I, Ferrer P, Silva-Martin N, Castro GR, Martinez-Ripoll M, Mobashery S, Hermoso JA J Biol Chem. 2011 Sep 9;286(36):31714-22. Epub 2011 Jul 20. PMID:21775432<ref>PMID:21775432</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Citrobacter freundii]] | [[Category: Citrobacter freundii]] | ||
[[Category: N-acetylmuramoyl-L-alanine amidase]] | [[Category: N-acetylmuramoyl-L-alanine amidase]] | ||
| - | [[Category: Andre, I | + | [[Category: Andre, I]] |
| - | [[Category: Barbe, S | + | [[Category: Barbe, S]] |
| - | [[Category: Carrasco-Lopez, C | + | [[Category: Carrasco-Lopez, C]] |
| - | [[Category: Hermoso, J A | + | [[Category: Hermoso, J A]] |
| - | [[Category: Hesek, D | + | [[Category: Hesek, D]] |
| - | [[Category: Lee, M | + | [[Category: Lee, M]] |
| - | [[Category: Martinez-Ripoll, M | + | [[Category: Martinez-Ripoll, M]] |
| - | [[Category: Mobashery, S | + | [[Category: Mobashery, S]] |
| - | [[Category: Rojas-Altuve, A | + | [[Category: Rojas-Altuve, A]] |
| - | [[Category: Silva-Martin, N | + | [[Category: Silva-Martin, N]] |
| - | [[Category: Zhang, W | + | [[Category: Zhang, W]] |
[[Category: Activation mechanism]] | [[Category: Activation mechanism]] | ||
[[Category: Amidase_2 family]] | [[Category: Amidase_2 family]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Peptidoglycan amidase]] | [[Category: Peptidoglycan amidase]] | ||
Revision as of 06:41, 24 December 2014
CRYSTAL STRUCTURE OF AMPD IN COMPLEX WITH REACTION PRODUCTS
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Categories: Citrobacter freundii | N-acetylmuramoyl-L-alanine amidase | Andre, I | Barbe, S | Carrasco-Lopez, C | Hermoso, J A | Hesek, D | Lee, M | Martinez-Ripoll, M | Mobashery, S | Rojas-Altuve, A | Silva-Martin, N | Zhang, W | Activation mechanism | Amidase 2 family | Hydrolase | Peptidoglycan amidase
