3l2a
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l2a RCSB], [http://www.ebi.ac.uk/pdbsum/3l2a PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l2a RCSB], [http://www.ebi.ac.uk/pdbsum/3l2a PDBsum]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == |
Revision as of 06:42, 24 December 2014
Crystal structure of Reston Ebola VP35 interferon inhibitory domain
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Categories: Reston ebolavirus | Amarasinghe, G K | Basler, C F | Borek, D M | Farahbakhsh, M | Leung, D W | Prins, K C | Host cytoplasm | Interferon antiviral evasion | Interferon antiviral system evasion | Rna binding domain | Rna binding protein | Rna replication | Rna-binding | Transcription | Virion