3l2a

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l2a RCSB], [http://www.ebi.ac.uk/pdbsum/3l2a PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l2a RCSB], [http://www.ebi.ac.uk/pdbsum/3l2a PDBsum]</span></td></tr>
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== Function ==
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[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 06:42, 24 December 2014

Crystal structure of Reston Ebola VP35 interferon inhibitory domain

3l2a, resolution 1.71Å

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