2kmi
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kmi RCSB], [http://www.ebi.ac.uk/pdbsum/2kmi PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kmi RCSB], [http://www.ebi.ac.uk/pdbsum/2kmi PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MESD2_MOUSE MESD2_MOUSE]] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Chen, J | + | [[Category: Chen, J]] |
| - | [[Category: Wang, J | + | [[Category: Wang, J]] |
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Lrp5/6]] | [[Category: Lrp5/6]] | ||
[[Category: Mesd/boca]] | [[Category: Mesd/boca]] | ||
Revision as of 06:45, 24 December 2014
MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6
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Categories: Mus musculus | Chen, J | Wang, J | Chaperone | Lrp5/6 | Mesd/boca
