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1l3x
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1l3x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_brevicaudus Gloydius brevicaudus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1iq2 1iq2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L3X FirstGlance]. <br> | <table><tr><td colspan='2'>[[1l3x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_brevicaudus Gloydius brevicaudus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1iq2 1iq2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L3X FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1laz|1laz]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1laz|1laz]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l3x RCSB], [http://www.ebi.ac.uk/pdbsum/1l3x PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l3x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l3x RCSB], [http://www.ebi.ac.uk/pdbsum/1l3x PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VM2HS_GLOBR VM2HS_GLOBR]] Metalloproteinase hxl-1: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).<ref>PMID:9722022</ref> <ref>PMID:9856345</ref> <ref>PMID:10446992</ref> <ref>PMID:10944460</ref> <ref>PMID:14977354</ref> Disintegrin salmosin-1: inhibits GPIIb/GPIIIa (ITGA2B/ITGB3) binding to immobilized fibrinogen with an IC(50) of 2.2 nM and ADP-induced platelet aggregation with an IC(50) of 131 nM, respectively. Inhibits angiogenesis.<ref>PMID:9722022</ref> <ref>PMID:9856345</ref> <ref>PMID:10446992</ref> <ref>PMID:10944460</ref> <ref>PMID:14977354</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Gloydius brevicaudus]] | [[Category: Gloydius brevicaudus]] | ||
| - | [[Category: Lee, W | + | [[Category: Lee, W]] |
| - | [[Category: Shin, J | + | [[Category: Shin, J]] |
[[Category: Disintegrin]] | [[Category: Disintegrin]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Rgd]] | [[Category: Rgd]] | ||
[[Category: Snake venome]] | [[Category: Snake venome]] | ||
Revision as of 07:05, 24 December 2014
Solution Structure of Novel Disintegrin Salmosin
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