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3p71
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p71 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p71 RCSB], [http://www.ebi.ac.uk/pdbsum/3p71 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p71 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p71 RCSB], [http://www.ebi.ac.uk/pdbsum/3p71 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LCMT1_HUMAN LCMT1_HUMAN]] Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.<ref>PMID:10600115</ref> [[http://www.uniprot.org/uniprot/PP2AA_HUMAN PP2AA_HUMAN]] PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.<ref>PMID:9920888</ref> <ref>PMID:10801873</ref> <ref>PMID:22613722</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Protein phosphatase|Protein phosphatase]] | ||
| + | *[[Serine/threonine protein phosphatase|Serine/threonine protein phosphatase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Phosphoprotein phosphatase]] | [[Category: Phosphoprotein phosphatase]] | ||
| - | [[Category: Jiang, L | + | [[Category: Jiang, L]] |
| - | [[Category: Satyshur, K A | + | [[Category: Satyshur, K A]] |
| - | [[Category: Stanevich, V | + | [[Category: Stanevich, V]] |
| - | [[Category: Xing, Y | + | [[Category: Xing, Y]] |
[[Category: Leucine carboxymethyltransferase-1]] | [[Category: Leucine carboxymethyltransferase-1]] | ||
[[Category: Methyltransferase]] | [[Category: Methyltransferase]] | ||
Revision as of 07:20, 24 December 2014
Crystal structure of the complex of LCMT-1 and PP2A
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