1vrq

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[[Image:1vrq.gif|left|200px]]<br /><applet load="1vrq" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1vrq.gif|left|200px]]
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caption="1vrq, resolution 2.20&Aring;" />
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'''Crystal Structure of Heterotetrameric Sarcosine Oxidase from Corynebacterium sp. U-96 in complex with Folinic Acid'''<br />
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{{Structure
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|PDB= 1vrq |SIZE=350|CAPTION= <scene name='initialview01'>1vrq</scene>, resolution 2.20&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=FON:FOLINIC+ACID'>FON</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene> and <scene name='pdbligand=DMG:N,N-DIMETHYLGLYCINE'>DMG</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Sarcosine_oxidase Sarcosine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.3.1 1.5.3.1]
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|GENE=
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}}
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'''Crystal Structure of Heterotetrameric Sarcosine Oxidase from Corynebacterium sp. U-96 in complex with Folinic Acid'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1VRQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Corynebacterium_sp. Corynebacterium sp.] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=FAD:'>FAD</scene>, <scene name='pdbligand=NAD:'>NAD</scene>, <scene name='pdbligand=FON:'>FON</scene>, <scene name='pdbligand=FMN:'>FMN</scene> and <scene name='pdbligand=DMG:'>DMG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Sarcosine_oxidase Sarcosine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.3.1 1.5.3.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRQ OCA].
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1VRQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Corynebacterium_sp. Corynebacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VRQ OCA].
==Reference==
==Reference==
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Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96., Ida K, Moriguchi T, Suzuki H, Biochem Biophys Res Commun. 2005 Jul 29;333(2):359-66. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15946648 15946648]
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Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96., Ida K, Moriguchi T, Suzuki H, Biochem Biophys Res Commun. 2005 Jul 29;333(2):359-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15946648 15946648]
[[Category: Corynebacterium sp.]]
[[Category: Corynebacterium sp.]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: heterotetrameric sarcosine oxidase]]
[[Category: heterotetrameric sarcosine oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:37:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:48:52 2008''

Revision as of 12:49, 20 March 2008

Image:1vrq.gif


PDB ID 1vrq

Drag the structure with the mouse to rotate
, resolution 2.20Å
Ligands: , , , , , and
Activity: Sarcosine oxidase, with EC number 1.5.3.1
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Heterotetrameric Sarcosine Oxidase from Corynebacterium sp. U-96 in complex with Folinic Acid


Overview

Sarcosine oxidase from Corynebacterium sp. U-96 is a heterotetrameric enzyme. Here we report the crystal structures of the enzyme in complex with dimethylglycine and folinic acid. The alpha subunit is composed of two domains, contains NAD(+), and binds folinic acid. The beta subunit contains dimethylglycine, FAD, and FMN, and these flavins are approximately 10A apart. The gamma subunit is in contact with two domains of alpha subunit and has possibly a folate-binding structure. The delta subunit contains a single atom of zinc and has a Cys(3)His zinc finger structure. Based on the structures determined and on the previous works, the structure-function relationship on the heterotetrameric sarcosine oxidase is discussed.

About this Structure

1VRQ is a Protein complex structure of sequences from Corynebacterium sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96., Ida K, Moriguchi T, Suzuki H, Biochem Biophys Res Commun. 2005 Jul 29;333(2):359-66. PMID:15946648

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