1vzv
From Proteopedia
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| - | [[Image:1vzv.gif|left|200px]] | + | [[Image:1vzv.gif|left|200px]] |
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| - | '''STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE''' | + | {{Structure |
| + | |PDB= 1vzv |SIZE=350|CAPTION= <scene name='initialview01'>1vzv</scene>, resolution 3.0Å | ||
| + | |SITE= <scene name='pdbsite=CAT:Catalytic+Triad'>CAT</scene> | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1VZV is a [ | + | 1VZV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Varicella-zoster_virus_(isolate_40a2) Varicella-zoster virus (isolate 40a2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VZV OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:[http:// | + | Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9096314 9096314] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Varicella-zoster virus (isolate 40a2)]] | [[Category: Varicella-zoster virus (isolate 40a2)]] | ||
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[[Category: viral protease]] | [[Category: viral protease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:50:15 2008'' |
Revision as of 12:50, 20 March 2008
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| , resolution 3.0Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE
Overview
Varicella-zoster virus (VZV), an alpha-herpes virus, is the causative agent of chickenpox, shingles, and postherpetic neuralgia. The three-dimensional crystal structure of the serine protease from VZV has been determined at 3.0-A resolution. The VZV protease is essential for the life cycle of the virus and is a potential target for therapeutic intervention. The structure reveals an overall fold that is similar to that recently reported for the serine protease from cytomegalovirus (CMV), a herpes virus of the beta subfamily. The VZV protease structure provides further evidence to support the finding that herpes virus proteases have a fold and active site distinct from other serine proteases. The VZV protease catalytic triad consists of a serine and two histidines. The distal histidine is proposed to properly orient the proximal histidine. The identification of an alpha-helical segment in the VZV protease that was mostly disordered in the CMV protease provides a better definition of the postulated active site cavity and reveals an elastase-like S' region. Structural differences between the VZV and CMV proteases also suggest potential differences in their oligomerization states.
About this Structure
1VZV is a Single protein structure of sequence from Varicella-zoster virus (isolate 40a2). Full crystallographic information is available from OCA.
Reference
Crystal structure of varicella-zoster virus protease., Qiu X, Janson CA, Culp JS, Richardson SB, Debouck C, Smith WW, Abdel-Meguid SS, Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2874-9. PMID:9096314
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