1w0i

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[[Image:1w0i.gif|left|200px]]<br /><applet load="1w0i" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1w0i.gif|left|200px]]
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caption="1w0i, resolution 2.10&Aring;" />
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'''ARABIDOPSIS THALIANA MITOCHONDRIAL KAS'''<br />
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{{Structure
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|PDB= 1w0i |SIZE=350|CAPTION= <scene name='initialview01'>1w0i</scene>, resolution 2.10&Aring;
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|SITE= <scene name='pdbsite=KAA:So4+Binding+Site+For+Chain+B'>KAA</scene>
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41]
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|GENE=
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}}
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'''ARABIDOPSIS THALIANA MITOCHONDRIAL KAS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1W0I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Known structural/functional Site: <scene name='pdbsite=KAA:So4+Binding+Site+For+Chain+B'>KAA</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0I OCA].
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1W0I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0I OCA].
==Reference==
==Reference==
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Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis., Olsen JG, Rasmussen AV, von Wettstein-Knowles P, Henriksen A, FEBS Lett. 2004 Nov 5;577(1-2):170-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15527780 15527780]
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Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis., Olsen JG, Rasmussen AV, von Wettstein-Knowles P, Henriksen A, FEBS Lett. 2004 Nov 5;577(1-2):170-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15527780 15527780]
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
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[[Category: synthase]]
[[Category: synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:50:27 2008''

Revision as of 12:50, 20 March 2008

Image:1w0i.gif


PDB ID 1w0i

Drag the structure with the mouse to rotate
, resolution 2.10Å
Sites:
Ligands: and
Activity: Beta-ketoacyl-acyl-carrier-protein synthase I, with EC number 2.3.1.41
Coordinates: save as pdb, mmCIF, xml



ARABIDOPSIS THALIANA MITOCHONDRIAL KAS


Overview

Mitochondrial fatty acid synthesis is catalyzed by a dissociated fatty acid synthase similar to those of plant plastids and bacteria. The crystal structure of a mitochondrial beta-ketoacyl-[acyl carrier protein] synthase (mtKAS), namely that from Arabidopsis thaliana, has been determined for the first time. This enzyme accomplishes the vital condensation steps in constructing fatty acid carbon skeletons. The product profile of mtKAS is unusual in that C8 and C(14-16) fatty acyl chains predominate. An enzyme architecture that likely is the basis for the observed bimodal profile of mtKAS products can be derived from the shape of the acyl binding pocket.

About this Structure

1W0I is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis., Olsen JG, Rasmussen AV, von Wettstein-Knowles P, Henriksen A, FEBS Lett. 2004 Nov 5;577(1-2):170-4. PMID:15527780

Page seeded by OCA on Thu Mar 20 14:50:27 2008

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