2y6w
From Proteopedia
(Difference between revisions)
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<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. <br> | + | <table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y6W FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1o0l|1o0l]], [[1zy3|1zy3]], [[1mk3|1mk3]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1o0l|1o0l]], [[1zy3|1zy3]], [[1mk3|1mk3]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [http://www.ebi.ac.uk/pdbsum/2y6w PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN]] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins.,Lee EF, Dewson G, Smith BJ, Evangelista M, Pettikiriarachchi A, Dogovski C, Perugini MA, Colman PM, Fairlie WD Structure. 2011 Oct 12;19(10):1467-76. PMID:22000515<ref>PMID:22000515</ref> | Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins.,Lee EF, Dewson G, Smith BJ, Evangelista M, Pettikiriarachchi A, Dogovski C, Perugini MA, Colman PM, Fairlie WD Structure. 2011 Oct 12;19(10):1467-76. PMID:22000515<ref>PMID:22000515</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Colman, P M | + | [[Category: Colman, P M]] |
| - | [[Category: Dogovski, C | + | [[Category: Dogovski, C]] |
| - | [[Category: Evangelista, M | + | [[Category: Evangelista, M]] |
| - | [[Category: Fairlie, W D | + | [[Category: Fairlie, W D]] |
| - | [[Category: Lee, E F | + | [[Category: Lee, E F]] |
| - | [[Category: Perugini, M A | + | [[Category: Perugini, M A]] |
| - | [[Category: Pettikiriarachchi, A | + | [[Category: Pettikiriarachchi, A]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
Revision as of 07:57, 24 December 2014
STRUCTURE OF A BCL-W DIMER
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