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1w1w

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[[Image:1w1w.gif|left|200px]]<br /><applet load="1w1w" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1w1w.gif|left|200px]]
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caption="1w1w, resolution 2.9&Aring;" />
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'''SC SMC1HD:SCC1-C COMPLEX, ATPGS'''<br />
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{{Structure
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|PDB= 1w1w |SIZE=350|CAPTION= <scene name='initialview01'>1w1w</scene>, resolution 2.9&Aring;
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+D'>AC1</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ATG:PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER'>ATG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''SC SMC1HD:SCC1-C COMPLEX, ATPGS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1W1W is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=ATG:'>ATG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W1W OCA].
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1W1W is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W1W OCA].
==Reference==
==Reference==
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Structure and stability of cohesin's Smc1-kleisin interaction., Haering CH, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Lowe J, Mol Cell. 2004 Sep 24;15(6):951-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15383284 15383284]
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Structure and stability of cohesin's Smc1-kleisin interaction., Haering CH, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Lowe J, Mol Cell. 2004 Sep 24;15(6):951-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15383284 15383284]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: mitosis]]
[[Category: mitosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:39:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:50:56 2008''

Revision as of 12:50, 20 March 2008

Image:1w1w.gif


PDB ID 1w1w

Drag the structure with the mouse to rotate
, resolution 2.9Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



SC SMC1HD:SCC1-C COMPLEX, ATPGS


Overview

A multisubunit complex called cohesin forms a huge ring structure that mediates sister chromatid cohesion, possibly by entrapping sister DNAs following replication. Cohesin's kleisin subunit Scc1 completes the ring, connecting the ABC-like ATPase heads of a V-shaped Smc1/3 heterodimer. Proteolytic cleavage of Scc1 by separase triggers sister chromatid disjunction, presumably by breaking the Scc1 bridge. One half of the SMC-kleisin bridge is revealed here by a crystal structure of Smc1's ATPase complexed with Scc1's C-terminal domain. The latter forms a winged helix that binds a pair of beta strands in Smc1's ATPase head. Mutation of conserved residues within the contact interface destroys Scc1's interaction with Smc1/3 heterodimers and eliminates cohesin function. Interaction of Scc1's N terminus with Smc3 depends on prior C terminus connection with Smc1. There is little or no turnover of Smc1-Scc1 interactions within cohesin complexes in vivo because expression of noncleavable Scc1 after DNA replication does not hinder anaphase.

About this Structure

1W1W is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and stability of cohesin's Smc1-kleisin interaction., Haering CH, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Lowe J, Mol Cell. 2004 Sep 24;15(6):951-64. PMID:15383284

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