1w5f

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[[Image:1w5f.jpg|left|200px]]<br /><applet load="1w5f" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1w5f.jpg|left|200px]]
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caption="1w5f, resolution 2.0&Aring;" />
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'''FTSZ, T7 MUTATED, DOMAIN SWAPPED (T. MARITIMA)'''<br />
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{{Structure
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|PDB= 1w5f |SIZE=350|CAPTION= <scene name='initialview01'>1w5f</scene>, resolution 2.0&Aring;
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|SITE= <scene name='pdbsite=AC1:G2p+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER'>G2P</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''FTSZ, T7 MUTATED, DOMAIN SWAPPED (T. MARITIMA)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1W5F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=G2P:'>G2P</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:G2p+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5F OCA].
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1W5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5F OCA].
==Reference==
==Reference==
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Structural insights into FtsZ protofilament formation., Oliva MA, Cordell SC, Lowe J, Nat Struct Mol Biol. 2004 Dec;11(12):1243-50. Epub 2004 Nov 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15558053 15558053]
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Structural insights into FtsZ protofilament formation., Oliva MA, Cordell SC, Lowe J, Nat Struct Mol Biol. 2004 Dec;11(12):1243-50. Epub 2004 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15558053 15558053]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: z-ring]]
[[Category: z-ring]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:40:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:52:22 2008''

Revision as of 12:52, 20 March 2008

Image:1w5f.jpg


PDB ID 1w5f

Drag the structure with the mouse to rotate
, resolution 2.0Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



FTSZ, T7 MUTATED, DOMAIN SWAPPED (T. MARITIMA)


Overview

The prokaryotic tubulin homolog FtsZ polymerizes into a ring structure essential for bacterial cell division. We have used refolded FtsZ to crystallize a tubulin-like protofilament. The N- and C-terminal domains of two consecutive subunits in the filament assemble to form the GTPase site, with the C-terminal domain providing water-polarizing residues. A domain-swapped structure of FtsZ and biochemical data on purified N- and C-terminal domains show that they are independent. This leads to a model of how FtsZ and tubulin polymerization evolved by fusing two domains. In polymerized tubulin, the nucleotide-binding pocket is occluded, which leads to nucleotide exchange being the rate-limiting step and to dynamic instability. In our FtsZ filament structure the nucleotide is exchangeable, explaining why, in this filament, nucleotide hydrolysis is the rate-limiting step during FtsZ polymerization. Furthermore, crystal structures of FtsZ in different nucleotide states reveal notably few differences.

About this Structure

1W5F is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structural insights into FtsZ protofilament formation., Oliva MA, Cordell SC, Lowe J, Nat Struct Mol Biol. 2004 Dec;11(12):1243-50. Epub 2004 Nov 21. PMID:15558053

Page seeded by OCA on Thu Mar 20 14:52:22 2008

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