2i4k
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2i4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I4K FirstGlance]. <br> | <table><tr><td colspan='2'>[[2i4k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I4K FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SNX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SNX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i4k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i4k RCSB], [http://www.ebi.ac.uk/pdbsum/2i4k PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i4k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i4k RCSB], [http://www.ebi.ac.uk/pdbsum/2i4k PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN]] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Gill, G N | + | [[Category: Gill, G N]] |
| - | [[Category: Hounslow, A M | + | [[Category: Hounslow, A M]] |
| - | [[Category: Lazar, C S | + | [[Category: Lazar, C S]] |
| - | [[Category: Waltho, J P | + | [[Category: Waltho, J P]] |
| - | [[Category: Watson, M J | + | [[Category: Watson, M J]] |
| - | [[Category: Zhong, Q | + | [[Category: Zhong, Q]] |
| - | [[Category: | + | [[Category: Alpha helice]] |
[[Category: 3-stranded beta sheet]] | [[Category: 3-stranded beta sheet]] | ||
[[Category: Proline rich loop]] | [[Category: Proline rich loop]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
Revision as of 08:27, 24 December 2014
Solution Structure of the PX domain of Sorting Nexin 1
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