2y37

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y37 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y37 RCSB], [http://www.ebi.ac.uk/pdbsum/2y37 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y37 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y37 RCSB], [http://www.ebi.ac.uk/pdbsum/2y37 PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Nitric-oxide synthase]]
[[Category: Nitric-oxide synthase]]
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[[Category: Andrews, G.]]
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[[Category: Andrews, G]]
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[[Category: Beaton, H G.]]
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[[Category: Beaton, H G]]
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[[Category: Birkinshaw, T N.]]
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[[Category: Birkinshaw, T N]]
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[[Category: Boughton-Smith, N.]]
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[[Category: Boughton-Smith, N]]
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[[Category: Cheshire, D R.]]
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[[Category: Cheshire, D R]]
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[[Category: Connolly, S.]]
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[[Category: Connolly, S]]
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[[Category: Cook, T R.]]
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[[Category: Cook, T R]]
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[[Category: Cooper, A.]]
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[[Category: Cooper, A]]
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[[Category: Cooper, S L.]]
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[[Category: Cooper, S L]]
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[[Category: Cox, D.]]
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[[Category: Cox, D]]
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[[Category: Dixon, J.]]
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[[Category: Dixon, J]]
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[[Category: Gensmantel, N.]]
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[[Category: Gensmantel, N]]
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[[Category: Hamley, P J.]]
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[[Category: Hamley, P J]]
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[[Category: Harrison, R.]]
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[[Category: Harrison, R]]
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[[Category: Hartopp, P.]]
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[[Category: Hartopp, P]]
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[[Category: Kack, H.]]
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[[Category: Kack, H]]
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[[Category: Luker, T.]]
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[[Category: Luker, T]]
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[[Category: Mete, A.]]
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[[Category: Mete, A]]
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[[Category: Millichip, I.]]
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[[Category: Millichip, I]]
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[[Category: Nicholls, D J.]]
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[[Category: Nicholls, D J]]
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[[Category: Pimm, A D.]]
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[[Category: Pimm, A D]]
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[[Category: St-Gallay, S A.]]
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[[Category: St-Gallay, S A]]
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[[Category: Wallace, A V.]]
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[[Category: Wallace, A V]]
[[Category: Drug design]]
[[Category: Drug design]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]

Revision as of 08:28, 24 December 2014

THE DISCOVERY OF NOVEL, POTENT AND HIGHLY SELECTIVE INHIBITORS OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS)

2y37, resolution 2.60Å

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