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1mff
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mff]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFF FirstGlance]. <br> | <table><tr><td colspan='2'>[[1mff]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFF FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mff RCSB], [http://www.ebi.ac.uk/pdbsum/1mff PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mff OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mff RCSB], [http://www.ebi.ac.uk/pdbsum/1mff PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MIF_MOUSE MIF_MOUSE]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Hackert, M L | + | [[Category: Hackert, M L]] |
| - | [[Category: Stamps, S L | + | [[Category: Stamps, S L]] |
| - | [[Category: Taylor, A B | + | [[Category: Taylor, A B]] |
| - | [[Category: Wang, S C | + | [[Category: Wang, S C]] |
| - | [[Category: Whitman, C P | + | [[Category: Whitman, C P]] |
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Inflammatory response]] | [[Category: Inflammatory response]] | ||
[[Category: Macrophage]] | [[Category: Macrophage]] | ||
[[Category: Tautomerase]] | [[Category: Tautomerase]] | ||
Revision as of 08:30, 24 December 2014
MACROPHAGE MIGRATION INHIBITORY FACTOR Y95F MUTANT
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