3p1a
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p1a RCSB], [http://www.ebi.ac.uk/pdbsum/3p1a PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p1a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p1a RCSB], [http://www.ebi.ac.uk/pdbsum/3p1a PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PMYT1_HUMAN PMYT1_HUMAN]] Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.<ref>PMID:9001210</ref> <ref>PMID:10373560</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:31, 24 December 2014
Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)
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Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Arrowsmith, C H | Berridge, G | Bountra, C | Chaikuad, A | Cooper, C D.O | Delft, F von | Edwards, A M | Eswaran, J | Fedorov, O | Knapp, S | Kroeler, T | Krojer, T | Muniz, J R.C | Pike, A C.W | Structural genomic | Vollmar, M | Weigelt, J | Membrane-associated protein kinase | Protein kinase | Sgc | Transferase | Tyrosine- and threonine-specific kinase
