2ecm
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ecm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECM FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ecm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ECM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rchy1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rchy1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ecm RCSB], [http://www.ebi.ac.uk/pdbsum/2ecm PDBsum], [http://www.topsan.org/Proteins/RSGI/2ecm TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ecm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ecm RCSB], [http://www.ebi.ac.uk/pdbsum/2ecm PDBsum], [http://www.topsan.org/Proteins/RSGI/2ecm TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ZN363_MOUSE ZN363_MOUSE]] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Harada, T | + | [[Category: Harada, T]] |
| - | [[Category: Kigawa, T | + | [[Category: Kigawa, T]] |
| - | [[Category: Koshiba, S | + | [[Category: Koshiba, S]] |
| - | [[Category: Miyamoto, K | + | [[Category: Miyamoto, K]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Watanabe, S | + | [[Category: Watanabe, S]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
| - | [[Category: Yoneyama, M | + | [[Category: Yoneyama, M]] |
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
[[Category: Rchy1]] | [[Category: Rchy1]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Ring domain]] | [[Category: Ring domain]] | ||
[[Category: Ring finger and chy zinc finger domain-containing protein 1]] | [[Category: Ring finger and chy zinc finger domain-containing protein 1]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Zinc-binding domain]] | [[Category: Zinc-binding domain]] | ||
Revision as of 08:31, 24 December 2014
Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus
| |||||||||||
Categories: Mus musculus | Harada, T | Kigawa, T | Koshiba, S | Miyamoto, K | Structural genomic | Watanabe, S | Yokoyama, S | Yoneyama, M | Metal binding protein | National project on protein structural and functional analyse | Nppsfa | Rchy1 | Ring domain | Ring finger and chy zinc finger domain-containing protein 1 | Rsgi | Zinc-binding domain
