2wf1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wf1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2wf1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY1:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-7-ETHYL-1-METHYL-3,4-DIHYDRO-1H-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE+2,2-DIOXIDE'>ZY1</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY1:N-{(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-7-ETHYL-1-METHYL-3,4-DIHYDRO-1H-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE+2,2-DIOXIDE'>ZY1</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tqf|1tqf]], [[1xn3|1xn3]], [[2vnm|2vnm]], [[1m4h|1m4h]], [[1xn2|1xn2]], [[2fdp|2fdp]], [[2viy|2viy]], [[2vie|2vie]], [[2va6|2va6]], [[2vj6|2vj6]], [[2viz|2viz]], [[2b8l|2b8l]], [[1ym4|1ym4]], [[1sgz|1sgz]], [[2va5|2va5]], [[1ujk|1ujk]], [[2b8v|2b8v]], [[1fkn|1fkn]], [[1xs7|1xs7]], [[2vij|2vij]], [[2va7|2va7]], [[1ym2|1ym2]], [[2vj9|2vj9]], [[2vkm|2vkm]], [[2vnn|2vnn]], [[1py1|1py1]], [[1w50|1w50]], [[1ujj|1ujj]], [[2vj7|2vj7]], [[1w51|1w51]], [[2wez|2wez]], [[2wf0|2wf0]], [[2wf2|2wf2]], [[2wf3|2wf3]], [[2wf4|2wf4]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tqf|1tqf]], [[1xn3|1xn3]], [[2vnm|2vnm]], [[1m4h|1m4h]], [[1xn2|1xn2]], [[2fdp|2fdp]], [[2viy|2viy]], [[2vie|2vie]], [[2va6|2va6]], [[2vj6|2vj6]], [[2viz|2viz]], [[2b8l|2b8l]], [[1ym4|1ym4]], [[1sgz|1sgz]], [[2va5|2va5]], [[1ujk|1ujk]], [[2b8v|2b8v]], [[1fkn|1fkn]], [[1xs7|1xs7]], [[2vij|2vij]], [[2va7|2va7]], [[1ym2|1ym2]], [[2vj9|2vj9]], [[2vkm|2vkm]], [[2vnn|2vnn]], [[1py1|1py1]], [[1w50|1w50]], [[1ujj|1ujj]], [[2vj7|2vj7]], [[1w51|1w51]], [[2wez|2wez]], [[2wf0|2wf0]], [[2wf2|2wf2]], [[2wf3|2wf3]], [[2wf4|2wf4]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
| - | [[Category: Brien, A O | + | [[Category: Brien, A O]] |
| - | [[Category: Charrier, N | + | [[Category: Charrier, N]] |
| - | [[Category: Clarke, B | + | [[Category: Clarke, B]] |
| - | [[Category: Demont, E | + | [[Category: Demont, E]] |
| - | [[Category: Dingwall, C | + | [[Category: Dingwall, C]] |
| - | [[Category: Dunsdon, R | + | [[Category: Dunsdon, R]] |
| - | [[Category: Hawkins, J | + | [[Category: Hawkins, J]] |
| - | [[Category: Hubbard, J | + | [[Category: Hubbard, J]] |
| - | [[Category: Hussain, I | + | [[Category: Hussain, I]] |
| - | [[Category: Maile, G | + | [[Category: Maile, G]] |
| - | [[Category: Matico, R | + | [[Category: Matico, R]] |
| - | [[Category: Mosley, J | + | [[Category: Mosley, J]] |
| - | [[Category: Naylor, A | + | [[Category: Naylor, A]] |
| - | [[Category: Redshaw, S | + | [[Category: Redshaw, S]] |
| - | [[Category: Rowland, P | + | [[Category: Rowland, P]] |
| - | [[Category: Smith, K J | + | [[Category: Smith, K J]] |
| - | [[Category: Soleil, V | + | [[Category: Soleil, V]] |
| - | [[Category: Sweitzer, S | + | [[Category: Sweitzer, S]] |
| - | [[Category: Theobald, P | + | [[Category: Theobald, P]] |
| - | [[Category: Vesey, D | + | [[Category: Vesey, D]] |
| - | [[Category: Walter, D S | + | [[Category: Walter, D S]] |
| - | [[Category: Wayne, G | + | [[Category: Wayne, G]] |
[[Category: Asp-2]] | [[Category: Asp-2]] | ||
[[Category: Aspartyl protease]] | [[Category: Aspartyl protease]] | ||
Revision as of 08:31, 24 December 2014
HUMAN BACE-1 IN COMPLEX WITH 7-ETHYL-N-((1S,2R)-2-HYDROXY-3-(((3-(METHYLOXY)PHENYL(METHYL)AMINO)-1-(PHENYLMETHYL) PROPYL)-1-METHYL-3,4-DIHYDRO-1H-(1,2,5)THIADIAZEPINO(3,4,5-HI)INDOLE-9-CARBOXAMIDE 2,2-DIOXIDE
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Categories: Homo sapiens | Memapsin 2 | Brien, A O | Charrier, N | Clarke, B | Demont, E | Dingwall, C | Dunsdon, R | Hawkins, J | Hubbard, J | Hussain, I | Maile, G | Matico, R | Mosley, J | Naylor, A | Redshaw, S | Rowland, P | Smith, K J | Soleil, V | Sweitzer, S | Theobald, P | Vesey, D | Walter, D S | Wayne, G | Asp-2 | Aspartyl protease | Bace-1 | Beta-secretase | Beta-site app cleaving enzyme | Disulfide bond | Glycoprotein | Hydrolase | Memapsin-2 | Membrane | Protease | Transmembrane | Zymogen
