4tuy

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4tuy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TUY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4tuy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TUY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=36L:(1R,2R,3E,5R,7R,8S,10S,13E,16R)-8-hydroxy-10-[(2S,3R,4E,6E,8E)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-2,7-dimethyl-6,11,19-trioxatricyclo[14.3.1.0~5,7~]icosa-3,13-diene-12,18-dione'>36L</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=36L:(1R,2R,3E,5R,7R,8S,10S,13E,16R)-8-hydroxy-10-[(2S,3R,4E,6E,8E)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-2,7-dimethyl-6,11,19-trioxatricyclo[14.3.1.0~5,7~]icosa-3,13-diene-12,18-dione'>36L</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i4t|4i4t]], [[4i50|4i50]], [[4i55|4i55]], [[4ihj|4ihj]], [[4iij|4iij]], [[4o2a|4o2a]], [[4o2b|4o2b]], [[4o4h|4o4h]], [[4o4i|4o4i]], [[4o4j|4o4j]], [[4o4l|4o4l]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i4t|4i4t]], [[4i50|4i50]], [[4i55|4i55]], [[4ihj|4ihj]], [[4iij|4iij]], [[4o2a|4o2a]], [[4o2b|4o2b]], [[4o4h|4o4h]], [[4o4i|4o4i]], [[4o4j|4o4j]], [[4o4l|4o4l]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tuy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tuy RCSB], [http://www.ebi.ac.uk/pdbsum/4tuy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tuy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tuy RCSB], [http://www.ebi.ac.uk/pdbsum/4tuy PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Altmann, K H.]]
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[[Category: Altmann, K H]]
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[[Category: Andreu, J M.]]
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[[Category: Andreu, J M]]
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[[Category: Bargsten, K.]]
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[[Category: Bargsten, K]]
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[[Category: Cuevas, C.]]
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[[Category: Cuevas, C]]
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[[Category: Diaz, J F.]]
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[[Category: Diaz, J F]]
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[[Category: Liniger, M.]]
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[[Category: Liniger, M]]
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[[Category: Marsh, M.]]
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[[Category: Marsh, M]]
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[[Category: Neuhaus, C.]]
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[[Category: Neuhaus, C]]
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[[Category: Prota, A E.]]
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[[Category: Prota, A E]]
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[[Category: Steinmetz, M O.]]
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[[Category: Steinmetz, M O]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: Rhizoxin]]
[[Category: Rhizoxin]]
[[Category: Tubulin fold]]
[[Category: Tubulin fold]]

Revision as of 08:35, 24 December 2014

Tubulin-Rhizoxin complex

4tuy, resolution 2.10Å

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