1w7j

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[[Image:1w7j.gif|left|200px]]<br /><applet load="1w7j" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1w7j.gif|left|200px]]
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caption="1w7j, resolution 2.&Aring;" />
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'''CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX- NEAR RIGOR'''<br />
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{{Structure
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|PDB= 1w7j |SIZE=350|CAPTION= <scene name='initialview01'>1w7j</scene>, resolution 2.&Aring;
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|SITE= <scene name='pdbsite=AC1:Bef+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=BEF:BERYLLIUM TRIFLUORIDE ION'>BEF</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX- NEAR RIGOR'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1W7J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=BEF:'>BEF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Bef+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7J OCA].
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1W7J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7J OCA].
==Reference==
==Reference==
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Three myosin V structures delineate essential features of chemo-mechanical transduction., Coureux PD, Sweeney HL, Houdusse A, EMBO J. 2004 Nov 24;23(23):4527-37. Epub 2004 Oct 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15510214 15510214]
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Three myosin V structures delineate essential features of chemo-mechanical transduction., Coureux PD, Sweeney HL, Houdusse A, EMBO J. 2004 Nov 24;23(23):4527-37. Epub 2004 Oct 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15510214 15510214]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: unconventional myosin]]
[[Category: unconventional myosin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:41:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:53:14 2008''

Revision as of 12:53, 20 March 2008

Image:1w7j.gif


PDB ID 1w7j

Drag the structure with the mouse to rotate
, resolution 2.Å
Sites:
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX- NEAR RIGOR


Overview

The molecular motor, myosin, undergoes conformational changes in order to convert chemical energy into force production. Based on kinetic and structural considerations, we assert that three crystal forms of the myosin V motor delineate the conformational changes that myosin motors undergo upon detachment from actin. First, a motor domain structure demonstrates that nucleotide-free myosin V adopts a specific state (rigor-like) that is not influenced by crystal packing. A second structure reveals an actomyosin state that favors rapid release of ADP, and differs from the rigor-like state by a P-loop rearrangement. Comparison of these structures with a third structure, a 2.0 angstroms resolution structure of the motor bound to an ATP analog, illuminates the structural features that provide communication between the actin interface and nucleotide-binding site. Paramount among these is a region we name the transducer, which is composed of the seven-stranded beta-sheet and associated loops and linkers. Reminiscent of the beta-sheet distortion of the F1-ATPase, sequential distortion of this transducer region likely controls sequential release of products from the nucleotide pocket during force generation.

About this Structure

1W7J is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three myosin V structures delineate essential features of chemo-mechanical transduction., Coureux PD, Sweeney HL, Houdusse A, EMBO J. 2004 Nov 24;23(23):4527-37. Epub 2004 Oct 28. PMID:15510214

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