1jum
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jum]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUM FirstGlance]. <br> | <table><tr><td colspan='2'>[[1jum]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jt0|1jt0]], [[1jt6|1jt6]], [[1jtx|1jtx]], [[1jty|1jty]], [[1jup|1jup]], [[1jus|1jus]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jt0|1jt0]], [[1jt6|1jt6]], [[1jtx|1jtx]], [[1jty|1jty]], [[1jup|1jup]], [[1jus|1jus]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jum RCSB], [http://www.ebi.ac.uk/pdbsum/1jum PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jum OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jum RCSB], [http://www.ebi.ac.uk/pdbsum/1jum PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 30: | Line 32: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
| - | [[Category: Brennan, R G | + | [[Category: Brennan, R G]] |
| - | [[Category: Brown, M H | + | [[Category: Brown, M H]] |
| - | [[Category: Grkovic, S | + | [[Category: Grkovic, S]] |
| - | [[Category: Miller, M C | + | [[Category: Miller, M C]] |
| - | [[Category: Schumacher, M A | + | [[Category: Schumacher, M A]] |
| - | [[Category: Skurray, R A | + | [[Category: Skurray, R A]] |
[[Category: Berberine]] | [[Category: Berberine]] | ||
[[Category: Multidrug binding]] | [[Category: Multidrug binding]] | ||
Revision as of 08:36, 24 December 2014
Crystal structure of the multidrug binding transcriptional repressor QacR bound to the natural drug berberine
| |||||||||||
