1w9n
From Proteopedia
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| - | [[Image:1w9n.gif|left|200px]] | + | [[Image:1w9n.gif|left|200px]] |
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| - | '''ISOLATION AND CHARACTERIZATION OF EPILANCIN 15X, A NOVEL ANTIBIOTIC FROM A CLINICAL STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS''' | + | {{Structure |
| + | |PDB= 1w9n |SIZE=350|CAPTION= <scene name='initialview01'>1w9n</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''ISOLATION AND CHARACTERIZATION OF EPILANCIN 15X, A NOVEL ANTIBIOTIC FROM A CLINICAL STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W9N is a [ | + | 1W9N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. |
==Reference== | ==Reference== | ||
| - | Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis., Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA, FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:[http:// | + | Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis., Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA, FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15792796 15792796] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus epidermidis]] | [[Category: Staphylococcus epidermidis]] | ||
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[[Category: lantibiotic]] | [[Category: lantibiotic]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:54:04 2008'' |
Revision as of 12:54, 20 March 2008
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ISOLATION AND CHARACTERIZATION OF EPILANCIN 15X, A NOVEL ANTIBIOTIC FROM A CLINICAL STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS
Overview
The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.
About this Structure
1W9N is a Single protein structure of sequence from Staphylococcus epidermidis. Full crystallographic information is available from OCA.
Reference
Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis., Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA, FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:15792796
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