1wcy

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[[Image:1wcy.gif|left|200px]]<br /><applet load="1wcy" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1wcy.gif|left|200px]]
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caption="1wcy, resolution 2.2&Aring;" />
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'''Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A'''<br />
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{{Structure
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|PDB= 1wcy |SIZE=350|CAPTION= <scene name='initialview01'>1wcy</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5]
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|GENE=
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}}
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'''Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1WCY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCY OCA].
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1WCY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCY OCA].
==Reference==
==Reference==
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The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A., Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R, Biol Chem. 2004 Jun;385(6):561-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15255191 15255191]
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The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A., Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R, Biol Chem. 2004 Jun;385(6):561-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15255191 15255191]
[[Category: Dipeptidyl-peptidase IV]]
[[Category: Dipeptidyl-peptidase IV]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: cd26]]
[[Category: cd26]]
[[Category: dipeptidyl peptidase iv]]
[[Category: dipeptidyl peptidase iv]]
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[[Category: diprotin a]]
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[[Category: diprotin some]]
[[Category: prolyl oligopeptidase]]
[[Category: prolyl oligopeptidase]]
[[Category: serine protease]]
[[Category: serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:43:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:55:22 2008''

Revision as of 12:55, 20 March 2008

Image:1wcy.gif


PDB ID 1wcy

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands:
Activity: Dipeptidyl-peptidase IV, with EC number 3.4.14.5
Coordinates: save as pdb, mmCIF, xml



Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A


Overview

Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, it seems important to develop selective inhibitors for human DPPIV (hDPPIV) that are able to control the biological function of hDPPIV. In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.

About this Structure

1WCY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A., Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R, Biol Chem. 2004 Jun;385(6):561-4. PMID:15255191

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