4rdn
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure of YTH-YTHDF2 in complex with m6A== |
| - | + | <StructureSection load='4rdn' size='340' side='right' caption='[[4rdn]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rdn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RDN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MD:N-METHYLADENOSINE'>6MD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rdo|4rdo]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rdn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rdn RCSB], [http://www.ebi.ac.uk/pdbsum/4rdn PDBsum]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN]] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Li, F D]] | ||
| + | [[Category: Shi, Y Y]] | ||
| + | [[Category: Wu, J H]] | ||
| + | [[Category: Zhao, D B]] | ||
| + | [[Category: Atypical beta-propeller]] | ||
| + | [[Category: M6a methylated rna]] | ||
| + | [[Category: M6a methylated rna binding]] | ||
| + | [[Category: Rna binding]] | ||
| + | [[Category: Rna binding protein]] | ||
Revision as of 10:55, 24 December 2014
Structure of YTH-YTHDF2 in complex with m6A
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