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4no5

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'''Unreleased structure'''
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==Crystal structure of non-phosphorylated form of AMPD2 phosphopeptide bound to HLA-A2==
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<StructureSection load='4no5' size='340' side='right' caption='[[4no5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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The entry 4no5 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4no5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NO5 FirstGlance]. <br>
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Authors: Mohammed, F., Stones, D.H., Willcox, B.E.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nnx|4nnx]], [[4nny|4nny]], [[4no0|4no0]], [[4no2|4no2]], [[4no3|4no3]]</td></tr>
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Description: Crystal structure of non-phosphorylated form of AMPD2 phosphopeptide bound to HLA-A2
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4no5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4no5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4no5 RCSB], [http://www.ebi.ac.uk/pdbsum/4no5 PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/AMPD2_HUMAN AMPD2_HUMAN]] Autosomal recessive spastic paraplegia type 63;Pontocerebellar hypoplasia type 9. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/AMPD2_HUMAN AMPD2_HUMAN]] AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.<ref>PMID:23911318</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Mohammed, F]]
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[[Category: Stones, D H]]
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[[Category: Willcox, B E]]
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[[Category: Immune system-antigen complex]]
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[[Category: Mhc]]
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[[Category: Nonphosphorylated peptide]]
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[[Category: Peptide conformation]]
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[[Category: Peptide-mhc complex]]
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[[Category: Post translational modification]]
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[[Category: Tumor antigen]]
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[[Category: Tumor immunology]]

Revision as of 11:06, 24 December 2014

Crystal structure of non-phosphorylated form of AMPD2 phosphopeptide bound to HLA-A2

4no5, resolution 2.10Å

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