4reb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer==
-
 
+
<StructureSection load='4reb' size='340' side='right' caption='[[4reb]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
-
The entry 4reb is ON HOLD until Paper Publication
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4reb]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4REB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4REB FirstGlance]. <br>
-
Authors: Zhao, Q., Xue, X., Longerich, S., Sung, P., Xiong, Y.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr>
-
 
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rea|4rea]], [[4rec|4rec]]</td></tr>
-
Description: Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4reb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4reb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4reb RCSB], [http://www.ebi.ac.uk/pdbsum/4reb PDBsum]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Longerich, S]]
 +
[[Category: Sung, P]]
 +
[[Category: Xiong, Y]]
 +
[[Category: Xue, X]]
 +
[[Category: Zhao, Q]]
 +
[[Category: Fancid2]]
 +
[[Category: Hjc]]
 +
[[Category: Hydrolase-dna complex]]
 +
[[Category: Nucleus]]
 +
[[Category: Sap]]
 +
[[Category: Structure specific nuclease]]
 +
[[Category: Tpr]]

Revision as of 11:10, 24 December 2014

Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer

4reb, resolution 4.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4reb"
Personal tools