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4rnb
From Proteopedia
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| - | ''' | + | ==Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant== |
| - | + | <StructureSection load='4rnb' size='340' side='right' caption='[[4rnb]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rnb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RNB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rnb RCSB], [http://www.ebi.ac.uk/pdbsum/4rnb PDBsum]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN]] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kolb, P]] | ||
| + | [[Category: Mobarec, J C]] | ||
| + | [[Category: Rosenbaum, D M]] | ||
| + | [[Category: Yin, J]] | ||
| + | [[Category: G protein-coupled receptor]] | ||
| + | [[Category: N-linked glycosylation]] | ||
| + | [[Category: Orexin neurotransmitter]] | ||
| + | [[Category: Orexin-a]] | ||
| + | [[Category: Orexin-b]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Suvorexant]] | ||
Revision as of 11:10, 24 December 2014
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant
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