4wj7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
==CCM2 PTB domain in complex with KRIT1 NPxY/F3==
-
 
+
<StructureSection load='4wj7' size='340' side='right' caption='[[4wj7]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-
The entry 4wj7 is ON HOLD until Paper Publication
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4wj7]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WJ7 FirstGlance]. <br>
-
Authors: Fisher, O.S., Liu, W., Zhang, R., Stiegler, A.L., Boggon, T.J.
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wj7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wj7 PDBsum]</span></td></tr>
-
 
+
</table>
-
Description:
+
== Disease ==
 +
[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Boggon, T J]]
 +
[[Category: Fisher, O S]]
 +
[[Category: Liu, W]]
 +
[[Category: Stiegler, A L]]
 +
[[Category: Zhang, R]]
 +
[[Category: Complex]]
 +
[[Category: Npxy motif]]
 +
[[Category: Ptb domain]]

Revision as of 11:15, 24 December 2014

CCM2 PTB domain in complex with KRIT1 NPxY/F3

4wj7, resolution 2.75Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wj7"
Personal tools