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4hur
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4hur]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUR FirstGlance]. <br> | <table><tr><td colspan='2'>[[4hur]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUR FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hus|4hus]], [[4e8l|4e8l]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hus|4hus]], [[4e8l|4e8l]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vat ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hur OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hur RCSB], [http://www.ebi.ac.uk/pdbsum/4hur PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hur OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hur RCSB], [http://www.ebi.ac.uk/pdbsum/4hur PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VATA_STAAU VATA_STAAU]] Inactivates the A compounds of virginiamycin-like antibiotics, thus providing resistance to these antibiotics. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Anderson, W F | + | [[Category: Anderson, W F]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Courvalin, P | + | [[Category: Courvalin, P]] |
| - | [[Category: Evdokimova, E | + | [[Category: Evdokimova, E]] |
| - | [[Category: Krishnamoorthy, M | + | [[Category: Krishnamoorthy, M]] |
| - | [[Category: Leo, R Di | + | [[Category: Leo, R Di]] |
| - | [[Category: Minasov, G | + | [[Category: Minasov, G]] |
| - | [[Category: Savchenko, A | + | [[Category: Savchenko, A]] |
| - | [[Category: Stogios, P J | + | [[Category: Stogios, P J]] |
| - | [[Category: Wawrzak, Z | + | [[Category: Wawrzak, Z]] |
| - | [[Category: Yim, V | + | [[Category: Yim, V]] |
[[Category: Acetyl coenzyme some]] | [[Category: Acetyl coenzyme some]] | ||
[[Category: Antibiotic resistance]] | [[Category: Antibiotic resistance]] | ||
| Line 42: | Line 44: | ||
[[Category: Streptogramin group a antibiotic acetyltransferase]] | [[Category: Streptogramin group a antibiotic acetyltransferase]] | ||
[[Category: Streptogramin group a antibiotic]] | [[Category: Streptogramin group a antibiotic]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Virginiamycin m1]] | [[Category: Virginiamycin m1]] | ||
Revision as of 11:21, 24 December 2014
Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with acetyl coenzyme A
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Categories: Anderson, W F | Structural genomic | Courvalin, P | Evdokimova, E | Krishnamoorthy, M | Leo, R Di | Minasov, G | Savchenko, A | Stogios, P J | Wawrzak, Z | Yim, V | Acetyl coenzyme some | Antibiotic resistance | Coenzyme some | Dalfopristin | Hexapeptide repeat acyltransferase | Intracellular | National institute of allergy and infectious disease | Niaid | Streptogramin some | Streptogramin group a antibiotic acetyltransferase | Streptogramin group a antibiotic | Transferase | Virginiamycin m1
