4pnk
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnk RCSB], [http://www.ebi.ac.uk/pdbsum/4pnk PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnk RCSB], [http://www.ebi.ac.uk/pdbsum/4pnk PDBsum]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN]] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref> [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: Elkins, J | + | [[Category: Elkins, J]] |
- | [[Category: Homan, K T | + | [[Category: Homan, K T]] |
- | [[Category: Knapp, S | + | [[Category: Knapp, S]] |
- | [[Category: Larimore, K M | + | [[Category: Larimore, K M]] |
- | [[Category: Tesmer, J J.G | + | [[Category: Tesmer, J J.G]] |
[[Category: Atp binding]] | [[Category: Atp binding]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] |
Revision as of 11:27, 24 December 2014
G protein-coupled receptor kinase 2 in complex with GSK180736A
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