4pnk

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnk RCSB], [http://www.ebi.ac.uk/pdbsum/4pnk PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnk RCSB], [http://www.ebi.ac.uk/pdbsum/4pnk PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN]] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref> [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Elkins, J.]]
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[[Category: Elkins, J]]
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[[Category: Homan, K T.]]
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[[Category: Homan, K T]]
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[[Category: Knapp, S.]]
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[[Category: Knapp, S]]
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[[Category: Larimore, K M.]]
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[[Category: Larimore, K M]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Tesmer, J J.G]]
[[Category: Atp binding]]
[[Category: Atp binding]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 11:27, 24 December 2014

G protein-coupled receptor kinase 2 in complex with GSK180736A

4pnk, resolution 2.56Å

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