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2r4r
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2r4r]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The April 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4R FirstGlance]. <br> | <table><tr><td colspan='2'>[[2r4r]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The April 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4R FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r4s|2r4s]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r4s|2r4s]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4r RCSB], [http://www.ebi.ac.uk/pdbsum/2r4r PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4r RCSB], [http://www.ebi.ac.uk/pdbsum/2r4r PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 39: | Line 41: | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Burghammer, M | + | [[Category: Burghammer, M]] |
| - | [[Category: Choi, H J | + | [[Category: Choi, H J]] |
| - | [[Category: Edwards, P C | + | [[Category: Edwards, P C]] |
| - | [[Category: Fischetti, R F | + | [[Category: Fischetti, R F]] |
| - | [[Category: Kobilka, B K | + | [[Category: Kobilka, B K]] |
| - | [[Category: Kobilka, T S | + | [[Category: Kobilka, T S]] |
| - | [[Category: Rasmussen, S G.F | + | [[Category: Rasmussen, S G.F]] |
| - | [[Category: Ratnala, V R | + | [[Category: Ratnala, V R]] |
| - | [[Category: Rosenbaum, D M | + | [[Category: Rosenbaum, D M]] |
| - | [[Category: Sanishvili, R | + | [[Category: Sanishvili, R]] |
| - | [[Category: Schertler, G F | + | [[Category: Schertler, G F]] |
| - | [[Category: Thian, F S | + | [[Category: Thian, F S]] |
| - | [[Category: Weis, W I | + | [[Category: Weis, W I]] |
[[Category: G-protein coupled receptor]] | [[Category: G-protein coupled receptor]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
Revision as of 13:30, 24 December 2014
Crystal structure of the human beta2 adrenoceptor
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Categories: Adrenergic Receptors | Homo sapiens | Mus musculus | RCSB PDB Molecule of the Month | Burghammer, M | Choi, H J | Edwards, P C | Fischetti, R F | Kobilka, B K | Kobilka, T S | Rasmussen, S G.F | Ratnala, V R | Rosenbaum, D M | Sanishvili, R | Schertler, G F | Thian, F S | Weis, W I | G-protein coupled receptor | Glycoprotein | Lipoprotein | Palmitate | Phosphorylation | Receptor | Signaling protein | Transducer | Transmembrane helix
