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2pe8

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2pe8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PE8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2pe8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PE8 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBM17, SPF45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RBM17, SPF45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pe8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pe8 RCSB], [http://www.ebi.ac.uk/pdbsum/2pe8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pe8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pe8 RCSB], [http://www.ebi.ac.uk/pdbsum/2pe8 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SPF45_HUMAN SPF45_HUMAN]] Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.<ref>PMID:12015979</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Basquin, J.]]
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[[Category: Basquin, J]]
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[[Category: Corsini, L.]]
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[[Category: Corsini, L]]
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[[Category: Hothorn, M.]]
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[[Category: Hothorn, M]]
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[[Category: Sattler, M.]]
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[[Category: Sattler, M]]
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Rrm]]
[[Category: Rrm]]

Revision as of 13:31, 24 December 2014

Crystal structure of the UHM domain of human SPF45 (free form)

2pe8, resolution 2.00Å

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