4k3c
From Proteopedia
(Difference between revisions)
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| - | + | ==The crystal structure of BamA from Haemophilus ducreyi lacking POTRA domains 1-3== | |
| - | + | <StructureSection load='4k3c' size='340' side='right' caption='[[4k3c]], [[Resolution|resolution]] 2.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4k3c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_ducreyi Haemophilus ducreyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K3C FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k3b|4k3b]]</td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D15, bamA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=730 Haemophilus ducreyi])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k3c RCSB], [http://www.ebi.ac.uk/pdbsum/4k3c PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/Q93PM2_HAEDC Q93PM2_HAEDC]] Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity).[HAMAP-Rule:MF_01430] | [[http://www.uniprot.org/uniprot/Q93PM2_HAEDC Q93PM2_HAEDC]] Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity).[HAMAP-Rule:MF_01430] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | beta-barrel membrane proteins are essential for nutrient import, signalling, motility and survival. In Gram-negative bacteria, the beta-barrel assembly machinery (BAM) complex is responsible for the biogenesis of beta-barrel membrane proteins, with homologous complexes found in mitochondria and chloroplasts. Here we describe the structure of BamA, the central and essential component of the BAM complex, from two species of bacteria: Neisseria gonorrhoeae and Haemophilus ducreyi. BamA consists of a large periplasmic domain attached to a 16-strand transmembrane beta-barrel domain. Three structural features shed light on the mechanism by which BamA catalyses beta-barrel assembly. First, the interior cavity is accessible in one BamA structure and conformationally closed in the other. Second, an exterior rim of the beta-barrel has a distinctly narrowed hydrophobic surface, locally destabilizing the outer membrane. And third, the beta-barrel can undergo lateral opening, suggesting a route from the interior cavity in BamA into the outer membrane. | ||
| - | + | Structural insight into the biogenesis of beta-barrel membrane proteins.,Noinaj N, Kuszak AJ, Gumbart JC, Lukacik P, Chang H, Easley NC, Lithgow T, Buchanan SK Nature. 2013 Sep 1. doi: 10.1038/nature12521. PMID:23995689<ref>PMID:23995689</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Haemophilus ducreyi]] | [[Category: Haemophilus ducreyi]] | ||
| - | [[Category: Buchanan, S K | + | [[Category: Buchanan, S K]] |
| - | [[Category: Chang, H | + | [[Category: Chang, H]] |
| - | [[Category: Easley, N | + | [[Category: Easley, N]] |
| - | [[Category: Lukacik, P | + | [[Category: Lukacik, P]] |
| - | [[Category: Noinaj, N | + | [[Category: Noinaj, N]] |
[[Category: Beta-barrel membrane protein]] | [[Category: Beta-barrel membrane protein]] | ||
[[Category: Insertase]] | [[Category: Insertase]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
Revision as of 13:32, 24 December 2014
The crystal structure of BamA from Haemophilus ducreyi lacking POTRA domains 1-3
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