1wt6

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[[Image:1wt6.gif|left|200px]]<br /><applet load="1wt6" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1wt6.gif|left|200px]]
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caption="1wt6, resolution 1.60&Aring;" />
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'''Coiled-Coil domain of DMPK'''<br />
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{{Structure
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|PDB= 1wt6 |SIZE=350|CAPTION= <scene name='initialview01'>1wt6</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Coiled-Coil domain of DMPK'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1WT6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT6 OCA].
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1WT6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT6 OCA].
==Reference==
==Reference==
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Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase., Garcia P, Marino M, Mayans O, Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2336-9. Epub, 2004 Nov 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15583383 15583383]
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Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase., Garcia P, Marino M, Mayans O, Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2336-9. Epub, 2004 Nov 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15583383 15583383]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: molecular replacement]]
[[Category: molecular replacement]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:47:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:01:10 2008''

Revision as of 13:01, 20 March 2008

Image:1wt6.gif


PDB ID 1wt6

Drag the structure with the mouse to rotate
, resolution 1.60Å
Coordinates: save as pdb, mmCIF, xml



Coiled-Coil domain of DMPK


Contents

Overview

The coiled-coil domain of dystrophia myotonica protein kinase (DMPK) has been cloned, overexpressed, purified and crystallized. Two crystal forms have been obtained that belong to space groups P3 and P2(1)2(1)2(1) and diffract to 2.4 and 1.6 A resolution, respectively. Experimental phases were obtained by MAD from an SeMet derivative. The location of selenium sites used molecular-replacement phases obtained from search models lacking sequence similarity with the coiled-coil under study. Both crystal forms contain three polypeptide chains in the asymmetric unit.

Disease

Known disease associated with this structure: Myotonic dystrophy OMIM:[605377]

About this Structure

1WT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase., Garcia P, Marino M, Mayans O, Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2336-9. Epub, 2004 Nov 26. PMID:15583383

Page seeded by OCA on Thu Mar 20 15:01:10 2008

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